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We next performed Chromatin Immunoprecipitation-Quantitative Polymerase Chain Reaction (ChIPqPCR) targeting conserved PARN promoter regions using IgG or SRF antibodies in MAT2A-overexpressing MNNG/HOS and U-2OS cells, which confirmed that MAT2A enhances PARN transcription by promoting SRF binding to its promoter (Fig