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This copper-dependent form of cell death is known as cuproptosis (13)

3.5 Cancers Currently, metabolic rewiring, which supports unrestricted proliferation and metastatic progression of cancer cells, is widely accepted to be an emerging hallmark of cancers (Petvri et al., 2020)

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For ING2 PHD , the cells were resuspended in a solution of 50 mM HEPES, 150 mM NaCl, and 2 mM DTT (pH = 7.5)

Quantification of Iba1 + cells was performed using ImageJ software, with results expressed as fluorescence intensity per mm 2 or mean fluorescence intensity (MFI)