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One group includes patients with family history that suggests a hereditary origin

They were also able to explain the appearance of an endemic cardiomyopathy known as Keshan disease in a Se-deficient area in north-east China detected in the early 1930s which mainly affected infants, children and women of childbearing age (Reference Li19)

This ensures that NRF2 remains at low levels under normal conditions but can be rapidly activated under stress conditions, helping the cell cope with oxidative damage and other harmful stimuli

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