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Five standard drinks require approximately five hours for full metabolic clearance in a healthy adult, per NIAAA pharmacokinetic data

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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

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doi: 10.1016/S0196-0644(98)70232-X

The ROS-mediated damage is further enhanced in older individuals since during aging, GSH levels appear to diminish in numerous tissues, thereby placing cells at increased risk of stress-related death (Maher, 2005)