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3.5.1 Inhibition of bEV virulence activity and destruction of bEV integrity Therapeutic strategies that demonstrate the ability to impact the integrity of bEVs and/or hinder the functions of their virulence factors have shown promise

Likewise, in an in vitro study, niacin (VB3) significantly reduced the secretion of the pro-inflammatory cytokine IL-8 from human hepatocytes (HepG2 and primary cells) that were stimulated with palmitic acid

Peroxiredoxin (PRX) was discovered in 1988 and is a novel peroxidase capable of reducing both hydroperoxides and peroxynitrate with the use of electrons provided by a physiological thiol like TRX (204, 205, 327)

However, its explicit role in the Y-H transition is yet to be explored [121]