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2nd Tier Biologics : Tofacitinib (Janus Kinase inhibitor) (often labeled a Targeted Biologic ) and other drugs in this subclass of medications have been found to be as effective as methotrexate, but their relatively higher incidence of biologic side effects for increased infections and cancer risk, as well as other side effects remain a cause for concern when their use is considered

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The associated accession numbers, coordinates and structure factors of the crystallographic complexes reported in this paper are available from the Protein Data Bank (PDB) with accession codes PDB: 8FI9 and 8FHY

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This treatment utilizes a plasma pen, which emits a small electric arc that creates micro-injuries on the skin's surface

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