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Hydroquinone and other skin lighteners work for those with dark pigmentation under their eyes (although do seek a doctors opinion first because usually darkness under the eyes is actually very thin skin with blood vessels showing through it - and lightening agents will not help, but could hurt thin skin) 5

doi: 10.1038/s41591-023-02543-w

Some common side effects of pemetrexed are: Upset stomach, nausea, and vomiting Diarrhea or constipation Changes in taste or loss of appetite Fatigue Sores in the mouth Temporary hair loss Rash Some patients using pemetrexed can experience severe nausea, diarrhea, and vomiting