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This is why acanthosis nigricans is commonly associated with: Overweight or obesity Type 2 diabetes Prediabetes Polycystic ovary syndrome (PCOS) Other hormonal or endocrine conditions In children and teenagers, its presence is often an early warning sign of insulin resistance long before diabetes develops

Nat Rev Nephrol (2018) 14:76781

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[ 419 ] Idiopathic Pulmonary fibrosis (IPF) is a chronic and advancing disease featuring diffuse inflammation, interstitial fibrosis, and the distortion of the lung framework, resulting in extensive impairment and dysfunction of the lungs

Sheng YY, Xiang J, Lu JL, et al

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