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for example, the autophagy receptor hippocalcin-like 1 (HPCAL1) promotes ferroptosis yet paradoxically facilitates NSCLC growth in vivo, suggesting that its net oncogenic role may involve pleiotropic functions beyond regulating this cell death pathway (77)

Jureidini J, Tonkin A

79 However, while specific examples of these mechanisms are being unravelled by detailed functional analysis in different contexts, how cancer mutations interact with various developmental, homoeostatic and regenerative programmes in support of cancer progression and metastasis is still poorly understood

7E, F) and elevated caspase-3 activity (Fig

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There are no known side effects of eating too much asparagus, but in large quantities, the fiber in the vegetable may cause diarrhea, gas, or bloating