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Ophthalmology 116 SchollH

DRUG INDUCED ACCUMULATION OF mtDNA DAMAGE Because mitochondria contain their own DNA, mitochondrial genome integrity is essential for organelle function

579 However, due to some side effects, it has not yet been approved for use in humans

In conclusion, we suggest that APR-246 exerts its cytotoxic effect through various cell death pathways

7.5 mg at a time) of methylfolate per day (morning and afternoon)

Testing antiretrovirals of the different classes according to their toxicity indexes resulted in an observation that the drug inducing the highest compromise of mitochondrial membrane potential was previously established as the least toxic, whereas the previously established most toxic drugs had variable effects of either decreasing or increasing mitochondrial membrane potential (Robertson et al