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Colonoscopy-based colorectal cancer modeling in mice with CRISPRCas9 genome editing and organoid transplantation

Nature 642, 492500

Long-term oral studies of acetylcysteine alone in rats (12 months of treatment followed by 6 months of observation) at doses up to 1,000 mg/kg/day (5.2 times the human mucolytic dose) provided no evidence of oncogenic activity