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Tumor hypoxia-activated combinatorial nanomedicine triggers systemic antitumor immunity to effectively eradicate advanced breast cancer

10.1067/j.cpradiol.2011.01.003 9

Both the PI3K/Akt and Ras/MAPK signaling will phosphorylate the proapoptotic protein BAD, causing inactivation due to cytoplasmic sequestration, which leads to enhanced platinum resistance by blocking apoptosis [114]

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a combination pharmaceutical is provided to ameliorate the detrimental effects of acetaminophen, a drug which consumes GSH in the liver during metabolism, and in excess doses causes liver damage due to oxidative damage