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Similarly, a study using a mouse model found that PNE produced hyperactivity that was associated with selective decreases in cingulate cortical volume and radial thickness and a decrease in drug-induced dopamine release in the frontal cortex [36]

There is no happy medium to be found between the tobacco industry and public health

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"And now we're being hit by the health consequences of tobacco use like none other." Still, McConnell noted, "I might seem like an unusual candidate to lead this charge." For many public health advocates, that was a vast understatement