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In medullary thyroid carcinoma models, decitabine plus the mTOR inhibitor everolimus demonstrated strong synergistic antiproliferation (synergy index CI = 0.1) and apoptosis (90% increase in late apoptotic/necrotic cells), mediated by activation of the NGFR-MAPK10-TP53-Bax/Bcl-2 pathway [99]

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