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demonstrated that ferroptosis, accompanied by decreased FNDC5 expression, occurs in both STZ-induced type 1 diabetic mouse bone tissue and high glucose-exposed MC3T3-E1 cells, with irisin administration or FNDC5 overexpression ameliorating type 1 diabetic bone loss via inhibition of endoplasmic reticulum stress-mediated ferroptosis [177]

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In addition, randomized trials have shown a small increase in the risk of incident diabetes

10.1021/ar300044j 63 ZhangH.LiangX.HanL.LiF

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