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Daru, 22 (1), 46

MPO, as a classical heme peroxidase, utilizes H 2 O 2 to oxidize a variety of aromatic compounds (RH) by a 1-electron mechanism to give substrate radicals (R) [154,155,156] (Fig

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It is hypothesized that in patients with PD, because of an increased proinflammatory state, the blood-brain barrier is even more permeable and as MRI studies show, iron accumulation targets neurons and glia of SN, putamen and globus pallidus (Ward et al., 2014)