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To directly evaluate the head-to-head weight-lowering potential of semaglutide versus GLP-1MK-801, we performed single intracerebroventricular (i.c.v.) infusions of equimolar concentrations of GLP-1MK-801 or semaglutide (Fig

Animal experiment also documented correlations of serum UA levels with lower striatal dopamine levels, tyrosine hydroxylase-positive neuronal death in the SN pars compacta, and the degree of oxidative stress in the midbrain

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