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These modifications alter its conformation, preventing Keap1 from effectively binding to the ETGE and DLG motifs of NRF2

Plant Physiol 118:14551461 Daud MK, Mei L, Azizullah A, Dawood M, Ali I, Mahmood Q, Ullah W, Jamil M, Zhu SJ (2016) Leaf-based physiological, metabolic, and ultrastructural changes in cultivated cotton cultivars under cadmium stress mediated by glutathione

Yant LJ, Ran Q, Rao L, Van Remmen H, Shibatani T, Belter JG et al (2003) The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

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Yes it supports immune function, liver detoxification, cellular repair and oxidative-stress reduction, which is why it features in broader detox and metabolic health programs

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