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Nuclear translocation of HIF-2 leads to the activation of target genes, including the iron uptake genes TFR1 and DMT1 in enterocytes ( Genetic alterations in JHDMs [Jumonji-C (JmjC) domain-containing histone demethylases] have been identified in various human cancers

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Transforming growth factor-1 and cigarette smoke inhibit the ability of 2-agonists to enhance epithelial permeability

The blue curve represents a healthy or early-injury lung: broad balanced zone, high efficiency

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