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The lyophilized format is preferred for research because it eliminates solution-phase degradation during storage and allows precise gravimetric preparation of research concentrations at the point of use

K., Han, K

Methionine oxidation is especially problematic

Osborne NN, Nunez-Alvarez C, Del Olmo-Aguado S, Merrayo-Lloves J

N-Aryl-N-(chroman-4-yl) ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis