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With poorly controlled or severe disease, there is risk that extra-articular manifestations such as keratitis, pulmonary granulomas (rheumatoid nodules), pericarditis/pleuritis, small vessel vasculitis, and other non-specific extra-articular symptoms will develop

Researchers investigating DSIPs interaction with stress-response pathways may also find it of interest alongside peptides like Selank, which has its own preclinical record in anxiety-related animal models, and Epitalon, which has been studied in aging and antioxidant contexts

DOI: org/10.1161/01.RES.79.6.1143 13

Unfortunately, even with this powerful medication, his acne just wasnt getting better

Proc Am Assoc Cancer Res 43:1099, 2002