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doi: 10.1016/j.lfs.2022.120867 24 JoshiAAVaidyaSSSt-PierreMVMikheevAMDesinoKENyandegeANet al

In vivo studies using two-photon fluorescence lifetime imaging and genetically encoded sensors (e.g., the laconic lactate biosensor) have confirmed that astrocytes generate lactate via glycolysis during neuronal activation, which is transported to neurons through monocarboxylate transporter MCT2