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The balance between pro- and anti-ferroptotic outcomes is largely dictated by the net effect of NO on the cellular redox state, specifically the ROS/GSH balance, and its targeted S-nitrosylation of key regulatory proteins

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As such, we are declining to modify the reporting incentive criteria to require the use of the eCQM collection type for reporting at least 3 of the 4 quality measures with this collection type in the proposed APP Plus quality measure set for the 2025 performance year

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Although the mechanism by which oxidizing agents is distinct from ionizing radiation, conditions like severe sepsis and septic shock also create an oxidation-rich environment that leads to the depletion of natural cellular antioxidants (such as glutathione) and contributes to cellular injury and death

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