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Geriatr Gerontol Int 12:180188

These advantages are derived from combinatorial actions enhancing brain antioxidant capacity while concurrently lowering cardiometabolic risk factors such as insulin resistance, obesity, and hypertension (Ellouze et al., 2023)

Chronic low-grade inflammation, increasingly recognized as a contributor to numerous age-related health conditions, may be partially mediated by inadequate antioxidant defenses including suboptimal glutathione status

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However, this pathway is reported to be inactive in most tissues, and in the few tissues in which it is active, its function is reduced in tumours from the corresponding tissue 16

Elevated levels of IL-1 and the activation of NLRP3 inflammasome were observed in SARS-CoV-2 infected patients [36, 37], implying that they are involved in immunologic defence mechanisms against COVID-19 infection