glutathione deficiency paracetamol Fasting depletes Glutathione, turning "safe" doses into a liver-toxic emergency. Don't let a therapeutic dose become a lethal one. See the safety protocols on BMJ Best Practice via bio. 🔍 #MedEd # Too much paracetamol = dangerous

Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem The competitive relationship between paracetamol sulfation and Download Scientific Diagram The diagram illustrates the process of paracetamol metabolism, which Download Scientific Diagram Metabolic pathway for NAPQI formation and detoxification by conjugation Download Scientific Diagram Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione depletion biomarkers ophthalmic acid and 5 oxoproline in humans and rats Integrative Biology (RSC Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S transferase Pi PNAS

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