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Intahphuak S, Khonsung P, Panthong A

The combination is used to prevent and manage deficiencies of these vitamins, to support pregnancy needs (folic acid), and to address peripheral neuropathy and macrocytic anaemia related to B12 and folate insufficiency

Most other candidates are re-purposed psychiatric medications

The C-terminal lysine is amidated (Lys-NH), preventing C-terminal degradation by carboxypeptidases

Cao Z, Tanaka M, Regnier C, Rothe M, Yamit-hezi A, Woronicz JD, Fuentes ME, Durnin MH, Dalrymple SA, Goeddel DV (1999) NF-kappa B activation by tumor necrosis factor and interleukin-1

Drugs called kinase inhibitors were developed to block this function, but these treatments have serious limitations