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25 Chronic alcohol consumption induces intestinal mycobiota overgrowth and translocation of fungal -glucan into the systemic circulation in mice

In context of AF, the metabolic disturbance of FAs was observed and proved to contribute to the predisposition and perpetuation of AF ( AF risk escalates in parallel with increased BMI, thus obesity, a public health issue as well as the most common metabolic disorder in human, is regarded as the second biggest attributable risk factor for AF ( Therefore, we adopted LCA (150 mg/kgBW/d) to facilitate FAO, and further examined the AF vulnerability and atrial remodeling in vivo (a mice model of high-fat diet (HFD)-induced obesity-mediated AF) and in vitro (a primary atrial cardiomyocyte cell model of palmitate (PA)-mimicked lipid overloading), aiming to determine whether enhancing FAO can alter the process that underlie AF in obesity and explore possible mechanisms

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To accommodate different contaminants, the resulting adsorbent offered many synergistic non-covalent forces as adsorption sites, such as stacking, hydrophobic interaction, hydrogen bonds, van der Waals forces, and electrostatic interactions, as illustrated in Fig