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While the exact function of this gene is still unknown, this points to PET100 as being another case of the founders mutation

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Both GSH and CME also tend to chelate with copper ions, and their respective conformations are GSH_a and CME_a, which interact with residues in the C1 region

Colchicine (Colcrys, Mitigare): using the matches analogy discussed above1, using colchicine can be seen as dampening the uric acid matches. Colchicine does not lower the bodys store of uric acid, but it decreases the intensity of the bodys inflammatory reaction to these crystals