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However, GSSG levels did not change substantially with aging in most of the 10 brain regions measured but declined significantly between 15 and 23 months of age in the brainstem, thalamus, and hypothalamus, while taurine levels also declined slightly ( C57BL/6J male mice showed a mean lifespan roughly 8% longer than C57BL/6N males, while C57BL/6J female mice showed a mean lifespan roughly 5% longer than C57BL/6N females (Ogiso et al., 2025)

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studied 65 pediatric patients with PFIC13 cholestatic disease and identified 27 different mutations that resulted in defective ATP8B1 , ABCB11 , and ABCB4