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This review synthesizes the current understanding of these intricate interactions, exploring how microbiota-driven modulation of the gut and brain barriers, immune signaling, and neuronal pathways, such as those through the vagus nerve, contributes to health and disease

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The results robustly demonstrated that the synergistic combination of curcumin with complementary agents exerts pleiotropic therapeutic effects in DED, addressing multiple pathophysiological pathways simultaneously

Immunohistochemical stains and electron microscopy can be used to identify the cell type involved

After staining, the brain tissue images were taken using a microscope, and the number of normal neurons and dark neurons in the cerebral cortex and hippocampus (CA1, CA3, DG) were counted using ImageJ software

When hPSCs reached approximately 70% confluency, the culture medium was switched to RPMI1640 supplemented with 1 B27