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L.Ortega-VillasanteC.et al

The oxygen of serine 40 is shown as a red sphere

Methylnat doesn't stop there

E., Sheehan, S

Here, certain amino-acid side-chains in the active site (specifically, their respective chemical properties), combined with the enzymes shape, lead to only one or at most a few types of molecules that can bind long enough for an irreversible chemical reaction to take place