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Phenotypic switching of VSMCs VSMCs normally maintain a contractile phenotype characterized by high expression of contractile proteins, such as -smooth muscle actin (SMA), smooth muscle myosin heavy chain (SM-MHC), and smooth muscle 22 (SM22) [129]

Notably, they observed chronic IL-6 signaling in CD4 + T cells, alongside an increased prevalence of plasma cells and CD11c + T-bet + CD211 low B cells

They demonstrated that they did not form BAs and could simultaneously break down putrescine and tyramine [65]

However, in severe cases, they can significantly impair vision and cause psychological distress, which may warrant medical intervention

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