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reported that 3,4-dihydroxyphenylpropionic acid (3,4-DHPPA), a major microbial metabolite of EC, suppressed pro-inflammatory cytokine production in hepatic macrophages during ischemia/reperfusion injury (HIRI)

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9,10 Mitochondria, which are critical for cellular respiration and metabolism, suffer damage to their own mitochondrial DNA by the actions of reactive oxygen species and peroxynitrite compounds, and they have been directly implicated in the process leading to cessation of ATP synthesis

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Some evidence suggests that due to TB4s ability to promote cell migration and angiogenesis, it could stimulate tumor metastasis (5)

Additionally, the Orange Book provides detailed patent information, which is crucial for companies involved in patent disputes or those planning to challenge existing patents to bring generics to market sooner