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Research is currently in progress to address some of these issues and, as mentioned, NICE guidelines for the diagnosis and management of vitamin B12 deficiency are in development

Pickart and Thaler isolated it from human serum in 1973 and characterized it as a tripeptide that prolongs survival of normal liver cells and stimulates growth in neoplastic liver tissue 17

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Additionally, significant associations were observed between single nucleotide variants in the NNMT gene and energy metabolism, obesity, T2D, hyperlipidemia, and hypertension (Zhu et al., 2016

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