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Compounds spanning 100-fold IC50 values for NNMT inhibition were selected on the basis of positional substitutions around the N-methylated quinolinium scaffold to obtain an estimate of drug-like oral absorption/bioavailability properties and guide the choice of inhibitors for in vitro and in vivo phenotypic studies

Gerdle B, Ghafouri B, Lund E, et al

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READ MORE: Hair loss treatment: An ancient oil shown to unplug hair follicles and boost hair growth The patients were subjected to Vitamin B12 assay and audiometry pre- and post-therapy