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The distal Ub C-terminus and the isopeptide bond are fully engulfed by the USP domain, with Glu159 of the thumb subdomain contacting the palm subdomain and coordinating the Gly76 amide backbone

This result suggests an inhibition of GPX4 as a potential measure to overcome drug resistance in breast cancer

Alpha-synuclein nitration and its implications in Parkinsons disease

Rodents overexpressing USP22 or lncRNA PART1 were well resistant to I/R-induced oxidative stress and cardiac injury, which may be partly attributed to the elevated GSH content in the myocardium [251, 252]

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and upregulate the activity of the epithelial cell marker E-cadherin (141)