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revealed that lactate can promote CD47-dependent immune evasion through histone lactylation reprogramming of GBM metabolism regulated by the heterochromatin component chromobox protein homolog 3 (CBX3), and additionally, histone lactylation can affect the immune microenvironment in GBM via interferon-regulated transcriptional programs ( Iron, as the core element of ferroptosis, is precisely regulated in the TME

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Famurewa AC, Edeogu CO, Offor FI, Besong EE, Akunna GG, Maduagwuna EK (2021) Downregulation of redox imbalance and iNOS/NF-B/caspase-3 signalling with zinc supplementation prevents urotoxicity of cyclophosphamide-induced hemorrhagic cystitis in rats