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Importantly, even in the absence of full caspase activation, BAX/BAK-mediated membrane permeabilization can still cause mtDNA leakage and trigger inflammatory responses [79]

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The findings aim to provide actionable insights for policymakers, clinicians, researchers and patients to advance DHT-driven, patient-centric approaches, ultimately improving patient outcomes and addressing the unmet medical needs of rare disease populations worldwide, ensuring they have equitable access to innovative treatments and improved healthcare

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