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is supported by the NIH/NCI (DP2 OD024174-01), NIH/NIDDK (R01 DK123323-01), Pershing Square Sohn Foundation and Mark Foundation Emerging Leader Award

Classical HT can be observed in 20% of thyroid patients diagnosed after birth

Synthesis of arginine from citrulline also occurs at a low level in many other cells, and cellular capacity for arginine synthesis can be markedly increased under circumstances that also induce iNOS

Chen, C

Altogether, these examples underscore that despite encouraging experimental results, ferroptosis-targeted drugs face multiple translational bottlenecks, including systemic toxicity, insufficient targeting, metabolic compensation, and biological heterogeneity

Walker RM, Gillespie BM, Thalib L, Higgins NS, Whitty JA