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20,21 Moreover, since its discovery, it has been recognized as a central molecule in energy metabolism, catalyzing extensive scientific investigations

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Apart from oxidation, there are several non-oxidative reactions of ethanol that lead to the enzymatic conjugation of this chemical to endogenous metabolites such as glucuronic acid, sulphate phospholipids, and fatty acids

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Acute toxicity studies in animals, if extrapolated to humans, implicate a single dose of 10-15 grams necessary to produce significant liver toxicity, although several human case reports have shown toxicity at doses less than 4 grams per day (likely due to having one or more risk factors for sensitivity to toxicity) (Amar 2007)