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Specifically, when IDO activity increases, more tryptophan is diverted away from serotonin synthesis and toward kynurenine

Oncotarget 6 , 97289739 (2015)

Gamma-glutamyl transpeptidase deficiency has been found in patients with CNS involvement and glutathionuria

Therapeutically, promising targeted strategies are highlighted, such as inhaled exosomes loaded with liproxstatin-1, which can selectively inhibit pulmonary ferroptosis without inducing system immunosuppression