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Doses exceeding 2,000 mg per day are generally considered high and are more likely to cause gastrointestinal side effects

Macrophage-encapsulated OMVs have been utilized to deliver Ce6 and doxorubicin to the 4T1 breast cancer cell line (146)

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Secondly, development of specific iron uptake by release of phytosiderophores for chelating iron ( +++ when released into the rhizosphere

Developing TME-responsive targeted delivery systems and combining ferroptosis inducers with immune checkpoint inhibitors or CAF inhibitors can enhance therapeutic efficacy and reduce toxicity ( In summary, ferroptosis holds great potential for the treatment of digestive tract tumors, but its clinical translation relies on in-depth deciphering of the interaction mechanisms between TME, immunity, and ferroptosis

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