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The reactions involved in Phase I metabolism include oxidation, reduction, and hydrolysis

[DOI] [PubMed] [Google Scholar] 45.Gocke DJ, Morris TQ, Bradley SE

Design, properties, and effective use of the oral chelator L1 and other alpha-ketohydroxypyridines in the treatment of transfusional iron overload in thalassemia

[Google Scholar] 37.Peel M.M., Cooke M., Lewis-Peel H.J., Lea R.A., Moyle W

10.1038/s12276-018-0183-1 Exp Mol Med

However, non-genetic mechanisms of resistance to cetuximab were also found, via TAF-mediated stromal remodeling and secretion of various growth factors, including FGF1, FGF2, HGF, TGF-1 and TGF-2 (80)