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Study on Ferroptosis Pathway that Operates in Hypertensive Brain Damage

Increased blood glucose levels induce excessive mitochondrial fission or fragmentation, thereby affecting OXPHOS, inhibit the expression of PINK1 and Parkin and downregulate the expression of genes such as PGC-1, thereby inhibiting mitochondrial biogenesis and mitophagy and preventing cells from eliminating abnormal mitochondria

doi: 10.1098/rstb.2013.0599 237 NeumannB.BarorR.ZhaoC.SegelM.DietmannS.RawjiK

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