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The ubiquitin-proteasome system (UPS) plays a critical role in maintaining protein metabolism equilibrium by degrading proteins such as cell cycle factors and regulatory proteins, thereby regulating numerous vital life activities and maintaining normal cell function

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Lazaro MT, Taxidis J, Shuman T, Bachmutsky I, Ikrar T, Santos R, et al

PMC 6688222

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Berberine induces dendritic cell apoptosis and has therapeutic potential for rheumatoid arthritis